By H. Maurice Goodman
Simple scientific Endocrinology, 3rd version presents up to date insurance of swiftly unfolding advances within the knowing of hormones enthusiastic about regulating so much points of physically services. The dialogue specializes in molecular and mobile facets of hormone creation and motion firmly rooted within the context of integrative body structure. subject matters are approached from the viewpoint of a physiologist with 4 a long time of training experience.
This ebook is richly illustrated with either descriptive schematic diagrams and laboratory findings got in scientific experiences. all the 13 in-depth chapters begins with an 'Overview' of the subject and ends with a 'Suggested interpreting' list.
* unmarried authorship presents continuity and consistency among chapters
* Richly illustrated with over 2 hundred illustrations
* IThirteen in-depth chapters incorporating the most recent insights gleaned from swiftly increasing genetic reviews of people and rodents
* writer has taught topic for over forty years
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Extra resources for Basic Medical Endocrinology, Third Edition
And corepressors that are available to complex with the receptor in that cell, and by the characteristics of the regulatory components in the DNA. Receptors for thyroid hormone and vitamin D and compounds related to vitamin A (retinoic acid) belong to another closely related group within the same family of proteins as the steroid receptors. Unlike the steroid hormone receptors, these receptors are bound to their HREs in DNA even in the absence of hormone, and do not form complexes with Hsp 90. In further distinction from the receptors for steroid hormones, receptors for thyroid hormone and vitamin D may bind to DNA either as homodimers or as heterodimers formed with a receptor for 9-cis-retinoic acid.
Dimers of phosphorylated CREBs bind to the CREs of regulated genes and recruit other nuclear proteins to form complexes that regulate gene transcription in the same manner as described for the nuclear hormone receptors. Desensitization and Down-Regulation In addition to simple dissociation of hormone from its receptor, signaling is often terminated and receptors desensitized to further stimulation by active cellular processes. G-Protein-coupled receptors may be inactivated by phosphorylation of one of their intracellular loops, catalyzed by a special G-protein receptor kinase, which uncouples the receptor from the alpha subunit and promotes binding to a cytoplasmic protein of the β-arrestin family.
42 Chapter 1. Introduction heat. A fall in blood glucose detected by the alpha cells of the islets of Langerhans causes them to release glucagon, which stimulates the liver to release glucose and thereby increase blood glucose concentrations (Figure 25). This simple example involves only secreting cells and responding cells.