Download Advances in Molecular and Cellular Endocrinology, Vol. 1 by Derek Leroith PDF

By Derek Leroith

Traditionally the sector of endocrine learn has consistently been on the vanguard of medical endeavors. The investigators of those vital breakthroughs in learn were rewarded by means of a variety of Nobel awards. within the box of diabetes on my own, Nobel prizes were presented to researchers who chanced on insulin, characterised the protein and invented radioimmunoassays utilizing insulin as a paradigm. now not strangely, biomedical researchers have continuously been attracted by means of the endocrine approach and different related structures of intercellular communique. during the last twenty years, endocrine study has built swiftly and tailored smooth molecular and mobile biology ideas for its particular use. those adjustments have allowed researchers within the box to take care of their area. therefore, endocrine disease-related genes were characterised and mutations in those genes have helped clarify universal and much less universal endocrine problems. Our figuring out of the legislation of gene expression has been tremendously superior through molecular innovations. In an try to convey investigators brand new with the hot advances during this exploding box now we have made up our minds to post a sequence entitled Advances in Molecular and mobile Endocrinology. the world over recognized investigators have agreed to take part and their contributions are liked. quantity 1 has all for facets of the hypothalamic-pituitary axis together with GnRH and GH gene law, molecular features of insulin, insulin-like progress elements and glucagon. moreover, studies at the lately cloned calcium receptor and steroid receptor interactions with DNA are awarded.

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1990). The partial purification and characterization of GnRH-like activity from prostatic biopsy specimens and prostatic cancer cell lines. J. Steroid Biochem. Molec. Biol. 37, 899-902. D. (1990). Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta. Mol. Endocrinol. 4, 476-480. , & Lee, E. (1992). Characterization, expression,, & estradiol regulation of the human GnRH gene. ), pp. 85-104. Springer-Verlag, New York. E. (1991). Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.

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Acad. Sci. USA 89, 8462-8466. J. (1993). Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic neurons. Proc. Natl. Acad. Sci. USA 90, 3908-3912. L. (1994). Hypothalamus-specific regulation of gonadotropin-releasing hormone gene expression. Recent Prog. Hormone Res. 50, 459-463. L. (1996). GATA-binding proteins are essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol. Cell. Biol.

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