Download Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall PDF

By Philip W. Harvey, David J. Everett, Christopher J. Springall

Despite being considered as the most typical toxicological objective within the endocrine method, the adrenal gland has usually been ignored in regulatory checking out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes recommendations on hand to check adrenal endocrine disruption.

Examining present ideas and the most recent developments, Adrenal Toxicology studies the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article presents info at the variety of substances and chemical compounds that have an effect on adrenocortical functionality and indicates standardized methods for in vivo and in vitro overview. This quantity additionally offers fresh advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the main advancements revamped the prior decade
  • focuses at the most recent study options, together with their makes use of and limitations
  • provides an built-in technique for adrenal toxicology evaluation
  • identifies wisdom and information gaps, offering impetus for regulatory consideration

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Example text

Liakos P, Lenz D, Bernhardt R, et al. Transforming growth factor beta1 inhibits aldosterone and cortisol production in the human adrenocortical cell line NCI-H295R through inhibition of CYP11B1 and CYP11 B2 expression. J Endocrinol 2003; 176:69–82. Liddle GW, Island DP, Lance EM, et al. Alterations in adrenal steroid patterns in man resulting from treatment with a chemical inhibitor of 11␤-hydroxylase. J Clin Endocrinol 1958; 18:906–912. Lin TCE, Chien SC, Hsu PC, et al. Mechanistic study of polychlorinated biphenyl 126induced CYP11B1 and CYP11 B2 up-regulation.

Ecotoxicology 2006; 15: 83–96. Chandra AK, Chatterjee A, Ghosh R, et al. Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats. Reprod Toxicol 2007; 24:388– 396. 26 Harvey et al. Chang HW, Wu VC, Huang CY, et al. D4 Dopamine receptor enhances angiotensin-II stimulated aldosterone secretion through PKC and calcium signalling. Am J Physiol Endocrinol Metab 2008; 294:E622–629. Chen QM, Alexander D, Sun H, et al. Corticosteroids inhibit cell death induced by doxorubicin in cardiomyocytes: Induction of antiapoptosis, antioxidant and detoxification genes.

Milkovic K, Joffe J, Levine S. The effects of maternal and fetal corticosteroids on the development and function of the pituitary-adrenocortical system. Endokrinologie 1976; 76:60–65. Adrenal Toxicology 31 Miller DB. Caveats in hazard assessment- stress and neurotoxicity. In: Isaacson RL, Jensen KF, eds. The Vulnerable Brain and Environmental Risks, Vol 1, Malnutrition and Hazard Assessment. New York, NY: Plenum, 1992:239–266. Montanaro D, Maggiolini M, Recchia AG, et al. Antiestrogens upregulate estrogen receptor beta expression and inhibit adrenocortical H295R cell proliferation.

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