Download 38th International Symposium on Growth Hormone and Growth by H. P. F. Koppeschaar, Torsten Tuvemo, Peter Trainer, Philip PDF

By H. P. F. Koppeschaar, Torsten Tuvemo, Peter Trainer, Philip Zeitler

Show description

Read Online or Download 38th International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism: Granada, Spain, April 7-8, 2006 (Hormone Research) PDF

Similar endocrinology books

Acute Endocrinology: From Cause to Consequence

The combination of endocrinology in severe care drugs has ended in new experimental and medical info at the advanced endocrine and metabolic derangements accompanying non-endocrine critical health problems. The becoming a member of of those disciplines has generated vital novel insights with major medical implications.

Pancreatic Cancer

This guide info advances in pancreatic melanoma study that experience a profound and lasting effect at the box. It positive factors the paintings of authors who're the superior of their respective fields and may have frequent charm between clinicians, pathologists and easy scientists who're now suffering to appreciate this complicated and swiftly increasing box.

Genetic Disorders of Endocrine Neoplasia (Frontiers of Hormone Research)

The genetics of endocrine cancers is obviously a space the place new medical discoveries that experience happened some time past few years have already been translated into medical perform. This quantity makes an attempt to supply a state of the art assessment of a few of the main correct inherited syndromes that percentage the next susceptibility to the advance of endocrine tumors.

Practical Algorithms

An set of rules is an answer to a category of difficulties ordinarily contained in programming unit referred to as a module and accessed through a number of objected orientated courses. a category on algorithms is a category on challenge fixing with the expectancy of marketable effects. This calls for a textbook that truly offers challenge fixing instruments.

Extra resources for 38th International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism: Granada, Spain, April 7-8, 2006 (Hormone Research)

Example text

Over the first 6 months of life, there is a gradual induction of GH-regulated growth that coincides with the appearance of growth hormonebinding protein in the circulation [23, 24], and by 18 months of age, linear growth is largely regulated through the GH/IGF-I axis. During childhood, serum GH and IGF-I levels continually rise, but with the onset of puberty, there is a dramatic increase in GH pulse amplitude with a concomitant increase in IGF-I generation that peaks at 1 year after peak height velocity [25–28].

12 Jørgensen JOL: Human growth hormone replacement therapy: pharmacological and clinical aspects. Endocr Rev 1991; 12: 189– 207. 13 Gotherstrom G, Svensson J, Koranyi J, Alpsten M, Bosaeus I, Bengtsson B, Johannsson G: A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices. J Clin Endocrinol Metab 2001;86:4657–4665. , USA Key Words Growth hormone ؒ Insulin-like growth factor I ؒ Growth hormone deficiency ؒ Insulin sensitivity ؒ Insulin secretion Abstract Background: The increased risk for development of type 2 diabetes mellitus (T2DM) in adults with growth hormone deficiency (GHD) has been attributed to insulin resistance arising from increased visceral fat accumulation and the putative effects of low insulin-like growth factor I (IGF-I) levels on pancreatic ␤-cell mass and insulin secretion.

1 mg/day are both physiological and more efficacious in improving glucose metabolism than standard GH doses titrated to normalise serum IGF-I levels. Low GH doses induced modest increments in free IGF-I without promoting lipolysis and thus contributed Horm Res 2007;67(suppl 1):37–42 39 to the beneficial effects on postabsorptive insulin sensitivity. However, it is yet to be determined whether ␤-cells are able to recover in patients with GHD, and risk for T2DM may persist even with low-dose therapy.

Download PDF sample

Rated 4.42 of 5 – based on 37 votes